Als

Als Stroll, Roll 'n' Run Moves Indoors

... brisket and sausage, green beans and potatoes with all the trimmings. There will also be live entertainment with the "Post Family Singers." The highlight of the event is always the competitive wheelchair race. Hassel said he challenges the adaptive sports team, the Bad News Chairs, to a race. This year, Pastor Bill will attach an airplane propeller on his wheelchair and hopes to finally win. The front parking lot will be used for the walk and run, while the wheelchair race will be inside Legacy Hall. Son Valley Ranch has seen major renovations and is nearing completion. Glen Dry, 42, owns the 27-acre property and is pastor of Sportsman's Church. He said the new facility will be perfect for the ALS race. "It's a great, large space," he said. "They don't have to worry about the weather that's given them trouble the past few years, so it's worked out great.". Dry has a personal connection to Lou Gehrig's disease. His uncle died from ALS 20 years ...

Former Eagle’s View Football Coach Ryan Keith Dies After Lengthy Als Battle

... passion for weightlifting. It didn’t matter who you were, he worked hard with every kid. Whether you had a little talent or a lot of talent.”. Keith resigned as a head coach following the 2013 season, although he wound up back at his alma mater, Trinity, after that to help out any way that he could. He was a common sight on the sidelines for the Conquerors during a couple of their four consecutive state championships before his health became too fragile. “Ryan was at peace with God, none of us could understand why this path was chosen for him, but he accepted it and I’m positive he realizes he was a blessing to others,” said former Eagle’s View baseball coach Terrance Freeman. “We will hurt a little bit, we’ll cry and we’ll just continue to share that story that Ryan preached to us all.”. Keith said he first noticed symptoms of ALS, which is commonly known as Lou Gehrig’s disease, in late 2006. He was diagnosed just over a year later. Despite the physical barriers — the relentless ...

A Potential Biomarker Of Als Progression

... et al., 1991 ; Ito et al., 2016 ). As part of the protein’s normal processing, the extracellular domain sheds from the cell surface and winds up in the urine ( Smith et al., 2015 ). Previously, Rogers and others reported that p 75 ECD levels are higher in patients’ urine than in controls ( Shepheard et al., 2014 ). In SOD 1 G 93 A ALS models, urine p 75 ECD climbs as the mice deteriorate, but it was unknown if that happens in ALS patients, too ( Matusica et al., 2016 ). To find out, first author Stephanie Shepheard at Flinders analyzed samples from the South Australian Motor Neuron Disease Clinic in Adelaide, and from the Kessenich Family ALS Center at the University of Miami. She used ELISA to measure p 75 in the urine of 54 ALS patients who averaged 64 years of age, as well as 45 of their healthy spouses and friends, average age 50. The researchers normalized urine p 75 ECD measurements to the levels of creatinine, a byproduct of muscle metabolism, in order to account for people’s hydration level. ALS patients ...

Zontivity May Increase Als Risk, But Certainty Will Be Difficult To Prove

... called Zontivity (vorapaxar) may be linked to a slight, but still increased, risk of amyotrophic lateral sclerosis (ALS), according to a review of U. S. Food and Drug Administration (FDA) documents on data from the drug’s clinical studies. While researchers noted that the risk of developing ALS is very small — about one case in every 10,000 treated people — they judged it likely to be tied to the treatment. Greater certainty will be difficult to ascertain, they said, as the extreme rarity of ALS in this population will continue to complicate efforts at reaching the sufficient numbers of patients needed for a clear answer through observational registries and postmarketing surveillance. The study, “Vorapaxar and Amyotrophic Lateral Sclerosis: Coincidence or Adverse Association?” was published in the American Journal of Therapeutics. ...

Family Rallies Around Mansfield Father Fighting Als

... his wife had to leave work to take care of him. ALS, also known as Lou Gehrig’s disease, is a progressive neurodegenerative disease that affects nerve cells in the brain and the spinal cord. As it progresses, people may lose the ability to speak, eat, move and breathe. “When they come in that room with the piece of paper basically to confirm it and basically say, ‘Go home and enjoy your family because here in America there's no cure, no treatment.’” Mike said. “So, it was tough. It was tough.”. The Romero family isn't giving up hope. “The frustration is a big part of it,” his wife Stephanie said. “I try to not get him frustrated. I want him to be happy.”. With help from a student fundraiser at Mansfield High School, where Mike’s son is a senior, Mike is well on his way to raising the $35,000 he needs to take part in a stem cell procedure in Thailand. Mike says it could save his life. ...

Randolph Resident Begins 2,200 Mile Appalachian Hike To Promote Als Research

... Therapy Development Institute. “Suddenly the noise in the back of my head said, ‘hey Rodger is three days younger than me, we both have been super active 56-year-olds, that could happen to me,’” Riecker said. “The question just kept growing louder and louder in my head and before you know it I was in pros and cons mode and wondered what I could do to honor Rodger in this whole process. So i decided to hike in honor of him, but beyond that, why not raise $100,000 to support ALS research and awareness.”. Riecker has since raised his goal of raising $100,000 to $1 million during his hike by collecting donations through the ALS Therapy Development Institutes fundraising page at Hike 4 __link__. As he passes through 14 states on his hike, Riecker is also scheduling interviews with media outlets and will be speaking with high school students in communities along the Appalachian Trail. Riecker has hiked all over the world, including Australia, Canada, Costa Rica, Belize, Zion, Bryce Canyon, and is now conquering the Appalachian Trail. He said he ...

Als Progression Can Be Measured Using Mri As Biomarker, Study Suggests

... Rating Score-Revised (ALSFRS-R), which measures daily living activities and global function of ALS patients. They also analyzed MRI-derived measures such as the thickness of the cerebral cortex (the brain’s outer layer) and the neck spinal cord. The team, whose research was funded by the São Paulo State Research Foundation, that although the cerebral cortex showed no progressive thinning in the cortex of the brain, people with ALS did show a  significant reduction in the volume of their  brainstem after eight months. The researchers also saw an increase in diffusivity, or the ability of water molecules to pass through a region of the brain called the corpus callosum. This relates to the loss of cerebral white matter integrity, a hallmark of ALS. However, these changes did not correlate with changes in the disease’s severity or ...

Neurofilament Light Chain As Prognostic Biomarker In Als

... after their lumbar puncture. In agreement with previous findings, Nf L concentration in the CSF inversely correlated with speed of disease progression as well as with overall survival, even after adjusting for sex, age, ALS subtype, and disease duration. UMND ALS presented the one exception to the rule. Although it is mild and slow-progressing, patients with this form had CSF Nf L as high as typical ALS. The authors speculated this reflects the predominantly upper corticospinal tract breakdown in UMND ALS. Could Nf L be useful for diagnosis? Based on their numbers, the authors suggest Nf L on its own can distinguish ALS from controls with nearly 90 percent sensitivity and specificity. However, the marker cannot distinguish ALS from FTD or other motor neuron disease with such certainty. “I’m less convinced about the diagnostic part of their study, but I think the evidence that correlates Nf L to ...